Exosome Therapy

These extracellular vesicles can also be used in stem cell therapies as a vehicle to take advantage of the beneficial cell signaling that occurs in the natural regeneration process to help control behavior of surrounding cells or to carry treatment doses in the bloodstream throughout the body including the ability to cross the blood-brain barrier [1] for promoting neurogenesis in treatments in neurodegenerative conditions, spinal cord injuries, strokes, brain injuries & bypass all other immune checkpoints in the body. The therapeutic potential in homing/migration of MSC cells and to hijack the neural stem cell messaging system via laboratory produced extracellular vesicles is especially powerful considering the same vesicles are also used by the body to spread disease, damaged proteins & genetic information for many conditions including Dementia, Parkinson’s disease along with metabolic disorders like obesity & diabetes.

Cancer cell-derived exosomes is another promising field with the goal of using exosomes to deliver vaccines or drugs in cancer immunotherapies, lung cancer treatments, prostate cancer treatment & treatment for pancreatic cancers. [2] These manufactured cancer exosome markers are able to send antigens to dendritic cells when then induces a T-cell-mediated response to surrounding cancer cells.

By enhancing the beneficial signals given out by stem cells scientist are able to manipulate exosomes behavior to solve medication delivery problems for many types of therapies including:

  • RNA therapies
  • Viral gene therapies
  • Small molecules
  • Proteins
  • CRISPR gene-editing

Doctors are hoping these isolate and purified exosomes vesicles (for immunoregulation) could one day become a new sector in regenerative medicine and stem cell treatments where MSC-derived exosomes are already being used for its healing properties in patients with COPD and pulmonary fibrosis lung disease.