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Azaheterocycles are some of the prevalent courses of compounds current in quite a few bioactive compounds, pure merchandise, and agrochemicals, and undoubtedly, new strategies to entry them are all the time in excessive demand. Among the many strategies accessible, the 1,3-dipolar cycloaddition reactions involving diazo compounds are significantly enticing due to their potential to quickly assemble densely functionalized azaheterocycles in a regioselective method.On this context, the Bestmann-Oh …

Peptide Synthesis Reagents, Coupling Reagents for Peptide Synthesis, Custom Synthesized Peptides, Resins, Peptides and Reagents.Peptide synthesis reagents We supply a very wide range of FMOC amino acids & Modified Amino Acids, Solvent: n-methyl pyrolidone (NMP), Dimethyl formamide (DMF), pipiridine, DMF Piperidine pre-mixes etc), Amino acid derivatives (FMOC's BOC's etc), linkers and resins (WANG, TentaGel etc) and coupling reagents in peptide synthesis. We also offer peptide synthesis, Cus …

The Basics of ELISA ImmunoassaysUnderstanding the basic principles of immunoassays is easy. The essential components of antibody-based immunoassay systems are threefold: an antigen to detect and perhaps quantitate; a specific antibody to this antigen; and a system to measure the amount of antigen in a given sample. Although it appears to be a very simple system, in many cases a number of other assay materials are necessary to allow for quick and convenient measurement.Featured TechNoteWhat are t …

Definition of an Enzyme To function, any organism needs energy.The production of this energy is based in particular on enzymes, proteins with catalytic properties and responsible for accelerating reactions in our cells.Almost 100% of the metabolic processes in our body require these molecules in order to function properly and therefore ensure the maintenance of life.Without enzyme , you run out of fuel!These small elements perform a large number of functions in living things: they contribute to …

The enzyme-substrate complex in the active siteLysozyme enzyme complex with its substrateThe folding of the peptide chain of the lysozyme, dominated by helical structures, creates a kind of invagination in which the substrate of the enzyme is lodged, represented here by the backbone of this small molecule. The close relationship between the enzyme and its substrate lowers ...Credits: RCSB PDB (rcsb.org) of 3GXR (Helland et al. 2009 Cell.Mol.Life Sci. 66: 2585-2598)Direct evidence of the formatio …