APPBP2 Antibody

APPBP2 Antibody | 7563 | ProSci

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: APPBP2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human APPBP2.
The immunogen is located within the last 50 amino acids of APPBP2.

Research Area: Neuroscience

Tested Application: E, WB, IHC-P, IF

Application: APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.

Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 2: Cat. No. 10-301 - Human Brain Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 64 kDa
Observed: 57 kDa

Validation: N/A

Isoform: N/A

Purification: APPBP2 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: APPBP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: APPBP2 Antibody: PAT1, APP-BP2, HS.84084, KIAA0228, PAT1, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2) , also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1) . The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2) . APPBP2 has been found to be highly expressed in breast cancer (3) .