SOD1(Superoxide dismutase [Cu-Zn]) Introduction

Superoxide dismutase [Cu-Zn] also known as superoxide dismutase 1 or SOD1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome 21. SOD1 is one of three human superoxide dismutases.[5][6] It is implicated in apoptosis and familial amyotrophic lateral sclerosis. SOD1 is a 32 kDa homodimer which forms a β-barrel and contains an intramolecular disulfide bond and a binuclear Cu/Zn site in each subunit. This Cu/Zn site holds the copper and a zinc ion and is responsible for catalyzing the disproportionation of superoxide to hydrogen peroxide and dioxygen. SOD1 binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.[8][10] Hydrogen peroxide can then be broken down by another enzyme called catalase.

Human SOD1(Superoxide dismutase [Cu-Zn]) ELISA Kit Test method

This kit uses sandwich ELISA to detect the concentration of SOD1(Superoxide dismutase [Cu-Zn]). SOD1 ELISA Kit allows for the in vitro quantitative determination of SOD1(Superoxide dismutase [Cu-Zn]) concentrations in serum, plasma, tissue homogenates and other biological fluids. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SOD1. 

Reference:

1, Salidroside inhibits the proliferation and migration of gastric carcinoma cells and tumor growth via the activation of ERS-dependent autophagy and apoptosis Wei Yan, et al,Rsc Advances,2019

2, Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase Zhang HT.et al,Protein Cell,2017

3, Effects of Cranberry-PACs against Urinary Problems associated with Radiotherapy in Iraqi Patients with Bladder Carcinoma Mohammed Basim Mohammed.et al,Int. J. Pharm. Sci. Rev. Res,2016