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ProSci

Alzheimers Disease B-Amyloid Protein Detection Set

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SKU:
PSI-1812
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  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
  • Alzheimers Disease B-Amyloid Protein Detection Set
€604.24

Description

Alzheimers Disease B-Amyloid Protein Detection Set | PSI-1812 | ProSci

 

Host: N/A

 

Reactivity: Human

 

Homology: N/A

 

Immunogen: Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.

 

Tested Application: WB, IHC

 

Application: These polyclonal antibodies can be used for detection of APP, BACE and BACE2 by immunoblot at 1 - 5 μgg/mL. APP and BACE antibodies can detect their respective proteins via immunohistochemistry at 2 - 10 μg/mL.

 

Specificity: Both APP antibodies will react with the C99 fragment of APP.

 

Purification: Antibodies are supplied as affinity chromatography purified IgG.

 

Clonality: Polyclonal

 

Isotype: N/A

 

Conjugate: N/A

 

Physical State: Liquid

 

Buffer: PBS containing 0.02% sodium azide.

 

Concentration: Antibody 1 mg/mL

 

Storage Condition: Stable at 4˚C for three months, store at -20˚C for up to one year.

 

Background: Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The βamyloid protein precursor (APP) is cleaved by one of two βsecretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for βsecretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer’s disease patients’ brains. BACE was identified by several groups independently and designated β-site APP cleaving enzyme (BACE) . BACE is a transmembrane aspartic protease and co-localizes with APP. BACE2 also cleaves APP at β-site and at a different site within Aβ. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and Aβ may also contribute to the pathogenesis of Down syndrome.

For images please see PDF data sheet

 

User Note: Optimal dilutions for each application to be determined by the researcher.

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Additional Information

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Species Reactivity:
Human
Size:
1 Set
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