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Exosomes and Secretome in Tissue Regeneration: Cell-Free Therapeutic Strategies Introduction Regenerative medicine is undergoing a transformative shift, moving beyond traditional cell-based therapies toward cell-free therapeutic approaches that harness the bioactive potential of cellular secretions. Among these, exosomes and the broader secretome have emerged as powerful mediators of tissue repair and regeneration. Rather than transplanting whole cells, researchers are increasingly focusing on t …