250 μg/mL Amphotericin B Solution

Background

Amphotericin B, also known as Lushanmycin, is a polyene antifungal antibiotic isolated from the culture supernatant of Streptomycesnodosus. Its antibacterial mechanism it can combine with ergosterol on the membrane of the fungus, resulting in cell membrane damage, the permeability is improved, thematerial inside the cell are leakaged, which disrupts normal metabolism and plays a bacteriostatic effect. Bacteria are ineffective because they do not contain ergosterol on their cell membranes. Amphotericin B has a broad antifungal spectrum, is effective against almost all fungi, and resistant strains are rare. It exhibits bactericidal effect at high concentrations. The amphotericin B solution is unstable at room temperature, easily damaged by light, heat and acid, and has the strongest antibacterial effect at pH 6.0-7.5.