RBP4(Retinol-binding protein 4) Introduction

Retinol binding protein 4, also known as RBP4, is a transporter protein for retinol (vitamin A alcohol). RBP4 has a molecular weight of approximately 21 kDa and is encoded by the RBP4 gene in humans.  It is mainly, though not exclusively, synthesized in the liver and circulates in the bloodstream bound to retinol in a complex with transthyretin. RBP4 has been a drug target for ophthalmology research due to its role in vision RBP4 may also be involved in metabolic diseases as suggested by recent studies.This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.

Human RBP4(Retinol-binding protein 4) ELISA Kit Test method

This kit uses sandwich ELISA to detect the concentration of RBP4(Retinol-binding protein 4). RBP4(Retinol-binding protein 4) ELISA Kit allows for the in vitro quantitative determination of RBP4(Retinol-binding protein 4) concentrations in serum, plasma, tissue homogenates and other biological fluids. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RBP4(Retinol-binding protein 4). 

Reference:

1, GRCh38: Ensembl release 89: ENSG00000138207 - Ensembl, May 2017

2, GRCm38: Ensembl release 89: ENSMUSG00000024990 - Ensembl, May 2017

3, "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.