Anti-PEG monoclonal antibody (DMABT-Z60567)

Rat Anti-PEG monoclonal antibody, clone Sbhq7
(DMABT-Z60567)

This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product :

• Overview The antibody can be employed to detect and quantify PEG-modified molecules in immunoblots, by ELISA and by WB.
  This is a rat IgM monoclonal antibody with specificity for the repeating subunits present in PEG.
• This clone displays high affinity and is able to bind a broad range of PEG molecules. A sensitive
  ELISA can be achieved utilizing this clone as a capture antibody and 7.4-biotin as the detection
  reagent. CHAPS instead of Tween-20 should be used in all washing buffers.

Specificity :

• This is a rat IgM monoclonal antibody with specificity for the repeating subunits present in PEG.
• This clone displays high affinity and is able to bind a broad range of PEG molecules. A sensitive
  ELISA can be achieved utilizing this clone as a capture antibody and 7.4-biotin as the detection
  reagent. CHAPS instead of Tween-20 should be used in all washing buffers.

Target : Polyethylene glycol
Isotype :  IgM
Source/Host : Rat
Species Reactivity : N/A
Clone : Sbhq7
Purification : Affinity Purified
Conjugate : Unconjugated
Applications : ELISA(Cap), WB
Format : Liquid
Concentration : Lot specific
Size : 500ug
Buffer : PBS
Preservative : 0.1% Sodium Azide
Storage : Long time storage is recommended at -20°C.

BACKGROUND

Introduction PEG (polyethylene glycol) is a water-soluble, nontoxic, biocompatible polymer that has been
approved by the Food and Drug Administration (FDA) for human intravenous, oral and dermal applications. Attachment of PEG chains to proteins can reduce their immunogenicity, minimize proteolytic cleavage and increase their serum half-life. PEG has also been attached to small molecules and liposomes for more selective delivery. PEG-modification of superparamagnetic iron oxide and quantum dots can improve their biocompatibility and reduce non-specific uptake.
PEG antibodies can be a vital tool for propelling therapeutics to market by serving as a positive control anti-drug antibody, measuring clearance of a drug, or simply as a QA release confirming PEGylation.